Publication list – javierorlandi.com

Last updated in 2022 (check Google Scholar instead)

Selected publications

Criticality in Spreading Processes without Timescale Separation and the Critical Brain Hypothesis
Korchinski, D.J., Orlandi, J.G., Son, S., and Davidsen, J.
Physical review x, vol. 11, iss.2, p. 21059, 2021.
[Bibtex]

@article{Korchinski2021,
abstract = {Spreading processes on networks are ubiquitous in both human-made and natural systems. Understanding their behavior is of broad interest; from the control of epidemics to understanding brain dynamics. While in some cases there exists a clear separation of time scales between the propagation of a single spreading cascade and the initiation of the next -- such that spreading can be modelled as directed percolation or a branching process -- there are also processes for which this is not the case, such as zoonotic diseases or spiking cascades in neural networks. For a large class of relevant network topologies, we show here that in such a scenario the nature of the overall spreading fundamentally changes. This change manifests itself in a transition between different universality classes of critical spreading, which determines the onset and the properties of an avalanche turning epidemic or neural activity turning epileptic, for example. We present analytical results in the mean-field limit giving the critical line along which scale-free spreading behaviour can be observed. The two limits of this critical line correspond to the universality classes of directed and undirected percolation, respectively. Outside these two limits, this duality manifests itself in the appearance of critical exponents from the universality classes of both directed and undirected percolation. We find that the transition between these exponents is governed by a competition between merging and propagation of activity, and identify an appropriate scaling relationship for the transition point. Finally, we show that commonly used measures, such as the branching ratio and dynamic susceptibility, fail to establish criticality in the absence of time-scale separation calling for a reanalysis of criticality in the brain.},
archivePrefix = {arXiv},
arxivId = {1908.08163},
author = {Korchinski, Daniel J. and Orlandi, Javier G. and Son, Seung-Woo and Davidsen, J{\"{o}}rn},
doi = {10.1103/PhysRevX.11.021059},
eprint = {1908.08163},
issn = {2160-3308},
journal = {Physical Review X},
keywords = {peer review,selected},
month = {jun},
number = {2},
pages = {021059},
title = {{Criticality in Spreading Processes without Timescale Separation and the Critical Brain Hypothesis}},
url = {https://arxiv.org/abs/1908.08163 https://link.aps.org/doi/10.1103/PhysRevX.11.021059},
volume = {11},
year = {2021}
}

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease
Fernández-García, S., Orlandi, J.G., {García-Díaz Barriga}, G.A., Rodríguez, M.J., Masana, M., Soriano, J., and Alberch, J.
Bmc biology, vol. 18, iss.1, p. 58, 2020.
[Bibtex]

@article{Fernandez-Garcia2020,
abstract = {Background: Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington's disease (HD), the cortico-striatal networks, involved in motor function processing, are the most compromised neural substrate. However, whether the network alterations are intrinsic of the striatum or the cortex is not fully understood. Results: In order to identify early HD neural deficits, we characterized neuronal ensemble calcium activity and network topology of HD striatal and cortical cultures. We used large-scale calcium imaging combined with activity-based network inference analysis. We extracted collective activity events and inferred the topology of the neuronal network in cortical and striatal primary cultures from wild-type and R6/1 mouse model of HD. Striatal, but not cortical, HD networks displayed lower activity and a lessened ability to integrate information. GABAA receptor blockade in healthy and HD striatal cultures generated similar coordinated ensemble activity and network topology, highlighting that the excitatory component of striatal system is spared in HD. Conversely, NMDA receptor activation increased individual neuronal activity while coordinated activity became highly variable and undefined. Interestingly, by boosting NMDA activity, we rectified striatal HD network alterations. Conclusions: Overall, our integrative approach highlights striatal defective network integration capacity as a major contributor of basal ganglia dysfunction in HD and suggests that increased excitatory drive may serve as a potential intervention. In addition, our work provides a valuable tool to evaluate in vitro network recovery after treatment intervention in basal ganglia disorders.},
author = {Fern{\'{a}}ndez-Garc{\'{i}}a, S. and Orlandi, J. G. and {Garc{\'{i}}a-D{\'{i}}az Barriga}, G. A. and Rodr{\'{i}}guez, M. J. and Masana, M. and Soriano, J. and Alberch, J.},
doi = {10.1186/s12915-020-00794-4},
file = {::},
issn = {17417007},
journal = {BMC Biology},
keywords = {peer review,selected},
month = {may},
number = {1},
pages = {58},
pmid = {32466798},
publisher = {BioMed Central Ltd.},
title = {{Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease}},
url = {https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-00794-4},
volume = {18},
year = {2020}
}

NETCAL: An interactive platform for large-scale, NETwork and population dynamics analysis of CALcium imaging recordings
Orlandi, J.G., Fernández-García, S., Comella-Bolla, A., Masana, M., {García-Díaz Barriga}, G., Yaghoubi, M., Kipp, A., Canals, J.M., Colicos, M.A., Davidsen, J., Alberch, J., and Soriano, J., Zenodo research data repository, 2017.
[Bibtex]

@misc{Orlandi2017b,
author = {Orlandi, Javier G. and Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and Comella-Bolla, Andrea and Masana, Merc{\`{e}} and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Yaghoubi, Mohammad and Kipp, Alexander and Canals, Josep M. and Colicos, Michael A. and Davidsen, J{\"{o}}rn and Alberch, Jordi and Soriano, Jordi},
doi = {doi.org/10.5281/zenodo.1119025},
keywords = {selected,software},
publisher = {Zenodo research data repository},
title = {{NETCAL: An interactive platform for large-scale, NETwork and population dynamics analysis of CALcium imaging recordings}},
url = {http://www.itsnetcal.com},
year = {2017}
}

First connectomics challenge: from imaging to connectivity
Orlandi, J.G., Ray, B., Battaglia, D., Guyon, I., Lemaire, V., Saeed, M., Soriano, J., Statnikov, A., and Stetter, O.
Journal of machine learning: workshop and conference proceedings, vol. 46, p. 1–22, 2015.
[Bibtex]

@article{Orlandi2015,
author = {Orlandi, Javier G. and Ray, Bisakha and Battaglia, Demian and Guyon, Isabelle and Lemaire, Vincent and Saeed, Mehreen and Soriano, Jordi and Statnikov, Alexander and Stetter, Olav},
journal = {Journal of Machine Learning: Workshop and Conference Proceedings},
keywords = {peer review,selected},
month = {oct},
pages = {1--22},
title = {{First connectomics challenge: from imaging to connectivity}},
url = {http://jmlr.org/proceedings/papers/v46/orlandi15.html},
volume = {46},
year = {2015}
}

Transfer Entropy Reconstruction and Labeling of Neuronal Connections from Simulated Calcium Imaging
Orlandi, J.G., Stetter, O., Soriano, J., Geisel, T., and Battaglia, D.
Plos one, vol. 9, iss.6, p. e98842, 2014.
[Bibtex]

@article{Orlandi2014a,
abstract = {Neuronal dynamics are fundamentally constrained by the underlying structural network architecture, yet much of the details of this synaptic connectivity are still unknown even in neuronal cultures in vitro. Here we extend a previous approach based on information theory, the Generalized Transfer Entropy, to the reconstruction of connectivity of simulated neuronal networks of both excitatory and inhibitory neurons. We show that, due to the model-free nature of the developed measure, both kinds of connections can be reliably inferred if the average firing rate between synchronous burst events exceeds a small minimum frequency. Furthermore, we suggest, based on systematic simulations, that even lower spontaneous inter-burst rates could be raised to meet the requirements of our reconstruction algorithm by applying a weak spatially homogeneous stimulation to the entire network. By combining multiple recordings of the same in silico network before and after pharmacologically blocking inhibitory synaptic transmission, we show then how it becomes possible to infer with high confidence the excitatory or inhibitory nature of each individual neuron.},
archivePrefix = {arXiv},
arxivId = {1309.4287},
author = {Orlandi, Javier G. and Stetter, Olav and Soriano, Jordi and Geisel, Theo and Battaglia, Demian},
doi = {10.1371/journal.pone.0098842},
editor = {Garcia-Ojalvo, Jordi},
eprint = {1309.4287},
file = {::},
isbn = {1932-6203 (Electronic)\r1932-6203 (Linking)},
issn = {1932-6203},
journal = {PLoS ONE},
keywords = {external,peer review,selected},
month = {jun},
number = {6},
pages = {e98842},
pmid = {24905689},
title = {{Transfer Entropy Reconstruction and Labeling of Neuronal Connections from Simulated Calcium Imaging}},
url = {http://dx.plos.org/10.1371/journal.pone.0098842 http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2013arXiv1309.4287O&link_type=ABSTRACT},
volume = {9},
year = {2014}
}

Noise focusing and the emergence of coherent activity in neuronal cultures
Orlandi, J.G., Soriano, J., Alvarez-Lacalle, E., Teller, S., and Casademunt, J.
Nature physics, vol. 9, iss.9, p. 582–590, 2013.
[Bibtex]

@article{Orlandi2013b,
abstract = {At early stages of development, neuronal cultures in vitro spontaneously reach a coherent state of collective firing in a pattern of nearly periodic global bursts. Although understanding the spontaneous activity of neuronal networks is of chief importance in neuroscience, the origin and nature of that pulsation has remained elusive. By combining high-resolution calcium imaging with modelling in silico, we show that this behaviour is controlled by the propagation of waves that nucleate randomly in a set of points that is specific to each culture and is selected by a non-trivial interplay between dynamics and topology. The phenomenon is explained by the noise focusing effect--a strong spatio-temporal localization of the noise dynamics that originates in the complex structure of avalanches of spontaneous activity. Results are relevant to neuronal tissues and to complex networks with integrate-and-fire dynamics and metric correlations, for instance, in rumour spreading on social networks.},
author = {Orlandi, Javier G. and Soriano, Jordi and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume},
doi = {10.1038/nphys2686},
file = {::;::},
isbn = {1745-2473},
issn = {1745-2473},
journal = {Nature Physics},
keywords = {peer review,selected},
month = {jul},
number = {9},
pages = {582--590},
pmid = {1000303108},
publisher = {Nature Publishing Group},
title = {{Noise focusing and the emergence of coherent activity in neuronal cultures}},
url = {http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2013NatPh...9..582O&link_type=ABSTRACT http://www.nonlinear.uni-bayreuth.de/en/index.html http://www.nature.com/doifinder/10.1038/nphys2686},
volume = {9},
year = {2013}
}

Under review

Deficiency of the ywhaz gene , involved in neurodevelopmental disorders , alters brain activity and behaviour in zebrafish
Antón-galindo, E., Vecchia, E.D., Orlandi, J.G., Castro, G., and Emilio, J.
Biorxiv, 2021.
[Bibtex]

@article{Anton-galindo2021,
author = {Ant{\'{o}}n-galindo, Ester and Vecchia, Elisa Dalla and Orlandi, Javier G and Castro, Gustavo and Emilio, J},
doi = {10.1101/2021.06.30.450513},
journal = {bioRxiv},
keywords = {underreview},
title = {{Deficiency of the ywhaz gene , involved in neurodevelopmental disorders , alters brain activity and behaviour in zebrafish}},
year = {2021}
}

Distributed context-dependent choice information in mouse dorsal-parietal cortex
Orlandi, J.G., Abdolrahmani, M., Aoki, R., Lyamzin, D.R., and Benucci, A., , , 2021.
[Bibtex]

@book{Orlandi2021a,
abstract = {Choice information appears in the brain as distributed signals with top-down and bottom-up components that together support decision-making computations. In sensory and associative cortical regions, the presence of choice signals, their strength, and area specificity are known to be elusive and changeable, limiting a cohesive understanding of their computational significance. In this study, examining the mesoscale activity in mouse posterior cortex during a complex visual discrimination task, we found that broadly distributed choice signals defined a decision variable in a low-dimensional embedding space of multi-area activations, particularly along the ventral visual stream. The subspace they defined was near-orthogonal to concurrently represented sensory and motor-related activations, and it was modulated by task difficulty and contextually by the animals' attention state. To mechanistically relate choice representations to decision-making computations, we trained recurrent neural networks with the animals' choices and found an equivalent decision variable whose context-dependent dynamics agreed with that of the neural data. In conclusion, our results demonstrated an independent decision variable broadly represented in the posterior cortex, controlled by task features and cognitive demands. Its dynamics reflected decision computations, possibly linked to context-dependent feedback signals used for probabilistic-inference computations in variable animal-environment interactions.},
author = {Orlandi, Javier G and Abdolrahmani, Mohammad and Aoki, Ryo and Lyamzin, Dmitry R and Benucci, Andrea},
journal = {bioRxiv},
doi = {10.1101/2021.03.02.433657},
isbn = {0000000276986},
keywords = {underreview},
pages = {2021.03.02.433657},
title = {{Distributed context-dependent choice information in mouse dorsal-parietal cortex}},
url = {https://doi.org/10.1101/2021.03.02.433657},
year = {2021}
}

Neuroligin 3 expression in astrocytes mediates neuron/glial communication
Orlandi, J.G., Hernandez, D., Leong, S., Davidsen, J., and Colicos, M.
Under review, 2021.
[Bibtex]

@article{Orlandi2020,
author = {Orlandi, Javier G. and Hernandez, Deyanell and Leong, Sarah and Davidsen, J{\"{o}}rn and Colicos, Michael},
journal = {Under review},
keywords = {underreview},
title = {{Neuroligin 3 expression in astrocytes mediates neuron/glial communication}},
year = {2021}
}

Sensory plasticity driven by single neurons in the mouse cortex
Aoki, R., Orlandi, J.G., and Benucci, A.
Under review, 2021.
[Bibtex]

@article{Aoki2021,
author = {Aoki, Ryo and Orlandi, Javier G. and Benucci, Andrea},
journal = {Under review},
keywords = {underreview},
title = {{Sensory plasticity driven by single neurons in the mouse cortex}},
year = {2021}
}

Peer-reviewed articles

2021

@article{Korchinski2021,
abstract = {Spreading processes on networks are ubiquitous in both human-made and natural systems. Understanding their behavior is of broad interest; from the control of epidemics to understanding brain dynamics. While in some cases there exists a clear separation of time scales between the propagation of a single spreading cascade and the initiation of the next -- such that spreading can be modelled as directed percolation or a branching process -- there are also processes for which this is not the case, such as zoonotic diseases or spiking cascades in neural networks. For a large class of relevant network topologies, we show here that in such a scenario the nature of the overall spreading fundamentally changes. This change manifests itself in a transition between different universality classes of critical spreading, which determines the onset and the properties of an avalanche turning epidemic or neural activity turning epileptic, for example. We present analytical results in the mean-field limit giving the critical line along which scale-free spreading behaviour can be observed. The two limits of this critical line correspond to the universality classes of directed and undirected percolation, respectively. Outside these two limits, this duality manifests itself in the appearance of critical exponents from the universality classes of both directed and undirected percolation. We find that the transition between these exponents is governed by a competition between merging and propagation of activity, and identify an appropriate scaling relationship for the transition point. Finally, we show that commonly used measures, such as the branching ratio and dynamic susceptibility, fail to establish criticality in the absence of time-scale separation calling for a reanalysis of criticality in the brain.},
archivePrefix = {arXiv},
arxivId = {1908.08163},
author = {Korchinski, Daniel J. and Orlandi, Javier G. and Son, Seung-Woo and Davidsen, J{\"{o}}rn},
doi = {10.1103/PhysRevX.11.021059},
eprint = {1908.08163},
issn = {2160-3308},
journal = {Physical Review X},
keywords = {peer review,selected},
month = {jun},
number = {2},
pages = {021059},
title = {{Criticality in Spreading Processes without Timescale Separation and the Critical Brain Hypothesis}},
url = {https://arxiv.org/abs/1908.08163 https://link.aps.org/doi/10.1103/PhysRevX.11.021059},
volume = {11},
year = {2021}
}

Noise-driven amplification mechanisms governing the emergence of coherent extreme events in excitable systems
Hernández-Navarro, L., Faci-Lázaro, S., Orlandi, J.G., Feudel, U., Gómez-Gardeñes, J., and Soriano, J.
Physical review research, vol. 3, iss.2, p. 23133, 2021.
[Bibtex]

@article{Hernandez-Navarro2021,
author = {Hern{\'{a}}ndez-Navarro, Llu{\'{i}}s and Faci-L{\'{a}}zaro, Sergio and Orlandi, Javier G. and Feudel, Ulrike and G{\'{o}}mez-Garde{\~{n}}es, Jes{\'{u}}s and Soriano, Jordi},
doi = {10.1103/PhysRevResearch.3.023133},
issn = {2643-1564},
journal = {Physical Review Research},
keywords = {peer review},
month = {may},
number = {2},
pages = {023133},
title = {{Noise-driven amplification mechanisms governing the emergence of coherent extreme events in excitable systems}},
url = {https://link.aps.org/doi/10.1103/PhysRevResearch.3.023133},
volume = {3},
year = {2021}
}

A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells
Mandwal, A., Orlandi, J.G., Simon, C., and Davidsen, J.
Plos one, vol. 16, iss.5, p. e0251172, 2021.
[Bibtex]

@article{Mandwal2019,
abstract = {Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop in tonic firing rate, i.e., the onset and the duration, depend upon the time interval between the onsets of the conditional and unconditional training stimuli. Direct stimulation of parallel fibers and climbing fiber by electrodes was found to be sufficient to reproduce the same characteristic drop in the firing rate of the Purkinje cell. In addition, the specific metabotropic glutamate-based receptor type 7 (mGluR 7 ) was found responsible for the initiation of the response, suggesting an intrinsic mechanism within the Purkinje cell for the temporal learning. In an attempt to look for a mechanism for time-encoding memory formation within individual Purkinje cells, we propose a biochemical mechanism based on recent experimental findings. The proposed mechanism tries to answer key aspects of the “Coding problem” of Neuroscience by focusing on the Purkinje cell's ability to encode time intervals through training. According to the proposed mechanism, the time memory is encoded within the dynamics of a set of proteins—mGluR 7 , G-protein, G-protein coupled Inward Rectifier Potassium ion channel, Protein Kinase A, Protein Phosphatase 1 and other associated biomolecules—which self-organize themselves into a protein complex. The intrinsic dynamics of these protein complexes can differ and thus can encode different time durations. Based on their amount and their collective dynamics within individual synapses, the Purkinje cell is able to suppress its own tonic firing rate for a specific time interval. The time memory is encoded within the effective dynamics of the biochemical reactions and altering these dynamics means storing a different time memory. The proposed mechanism is verified by both a minimal and a more comprehensive mathematical model of the conditional response behavior of the Purkinje cell and corresponding dynamical simulations of the involved biomolecules, yielding testable experimental predictions.},
author = {Mandwal, Ayush and Orlandi, Javier G. and Simon, Christoph and Davidsen, J{\"{o}}rn},
doi = {10.1371/journal.pone.0251172},
editor = {Bosman, Laurens W. J.},
issn = {1932-6203},
journal = {PLOS ONE},
keywords = {peer review},
month = {may},
number = {5},
pages = {e0251172},
title = {{A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells}},
url = {https://dx.plos.org/10.1371/journal.pone.0251172},
volume = {16},
year = {2021}
}

Inferring excitatory and inhibitory connections in neuronal networks
Ghirga, S., Chiodo, L., Marrocchio, R., Orlandi, J.G., and Loppini, A.
Entropy, vol. 23, iss.9, p. 1–17, 2021.
[Bibtex]

@article{Ghirga2021,
abstract = {The comprehension of neuronal network functioning, from most basic mechanisms of signal transmission to complex patterns of memory and decision making, is at the basis of the modern research in experimental and computational neurophysiology. While mechanistic knowledge of neurons and synapses structure increased, the study of functional and effective networks is more complex, involving emergent phenomena, nonlinear responses, collective waves, correlation and causal interactions. Refined data analysis may help in inferring functional/effective interactions and connectivity from neuronal activity. The Transfer Entropy (TE) technique is, among other things, well suited to predict structural interactions between neurons, and to infer both effective and structural connectivity in small-and large-scale networks. To efficiently disentangle the excitatory and inhibitory neural activities, in the article we present a revised version of TE, split in two contributions and characterized by a suited delay time. The method is tested on in silico small neuronal networks, built to simulate the calcium activity as measured via calcium imaging in two-dimensional neuronal cultures. The inhibitory connections are well characterized, still preserving a high accuracy for excitatory connections prediction. The method could be applied to study effective and structural interactions in systems of excitable cells, both in physiological and in pathological conditions.},
author = {Ghirga, Silvia and Chiodo, Letizia and Marrocchio, Riccardo and Orlandi, Javier G. and Loppini, Alessandro},
doi = {10.3390/e23091185},
issn = {10994300},
journal = {Entropy},
keywords = {peer review},
number = {9},
pages = {1--17},
title = {{Inferring excitatory and inhibitory connections in neuronal networks}},
volume = {23},
year = {2021}
}

Stochastic quorum percolation and noise focusing in neuronal networks
{Orlandi, J.G.}. and {Casademunt, J.
Epl, vol. 133, iss.4, p. 48002, 2021.
[Bibtex]

@article{Orlandi2021,
author = {{Orlandi, Javier G.} and {Casademunt, Jaume}},
title = {Stochastic quorum percolation and noise focusing in neuronal networks},
DOI= "10.1209/0295-5075/133/48002",
url= "https://doi.org/10.1209/0295-5075/133/48002",
journal = {EPL},
year = 2021,
volume = 133,
number = 4,
pages = "48002",
keywords = {peer review}
}

2020

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation
Comella-Bolla, A., Orlandi, J.G., Miguez, A., Straccia, M., García-Bravo, M., Bombau, G., Galofré, M., Sanders, P., Carrere, J., Segovia, J.C., Blasi, J., Allen, N.D., Alberch, J., Soriano, J., and Canals, J.M.
Molecular neurobiology, vol. 57, iss.6, p. 2766–2798, 2020.
[Bibtex]

@article{Comella-Bolla2020,
abstract = {Human pluripotent stem cells (hPSCs) are a powerful tool for modelling human development. In recent years, hPSCs have become central in cell-based therapies for neurodegenerative diseases given their potential to replace affected neurons. However, directing hPSCs into specific neuronal types is complex and requires an accurate protocol that mimics endogenous neuronal development. Here we describe step-by-step a fast feeder-free neuronal differentiation protocol to direct hPSCs to mature forebrain neurons in 37 days in vitro (DIV). The protocol is based upon a combination of specific morphogens, trophic and growth factors, ions, neurotransmitters and extracellular matrix elements. A human-induced PSC line (Ctr-Q33) and a human embryonic stem cell line (GEN-Q18) were used to reinforce the potential of the protocol. Neuronal activity was analysed by single-cell calcium imaging. At 8 DIV, we obtained a homogeneous population of hPSC-derived neuroectodermal progenitors which self-arranged in bi-dimensional neural tube-like structures. At 16 DIV, we generated hPSC-derived neural progenitor cells (NPCs) with mostly a subpallial identity along with a subpopulation of pallial NPCs. Terminal in vitro neuronal differentiation was confirmed by the expression of microtubule associated protein 2b (Map 2b) by almost 100% of hPSC-derived neurons and the expression of specific-striatal neuronal markers including GABA, CTIP2 and DARPP-32. HPSC-derived neurons showed mature and functional phenotypes as they expressed synaptic markers, voltage-gated ion channels and neurotransmitter receptors. Neurons displayed diverse spontaneous activity patterns that were classified into three major groups, namely “high”, “intermediate” and “low” firing neurons. Finally, transplantation experiments showed that the NPCs survived and differentiated within mouse striatum for at least 3 months. NPCs integrated host environmental cues and differentiated into striatal medium-sized spiny neurons (MSNs), which successfully integrated into the endogenous circuitry without teratoma formation. Altogether, these findings demonstrate the potential of this robust human neuronal differentiation protocol, which will bring new opportunities for the study of human neurodevelopment and neurodegeneration, and will open new avenues in cell-based therapies, pharmacological studies and alternative in vitro toxicology.},
author = {Comella-Bolla, Andrea and Orlandi, Javier G. and Miguez, Andr{\'{e}}s and Straccia, Marco and Garc{\'{i}}a-Bravo, Mar{\'{i}}a and Bombau, Georgina and Galofr{\'{e}}, Mireia and Sanders, Phil and Carrere, Jordi and Segovia, Jos{\'{e}} Carlos and Blasi, Joan and Allen, Nicholas D. and Alberch, Jordi and Soriano, Jordi and Canals, Josep M.},
doi = {10.1007/s12035-020-01907-4},
file = {::},
issn = {15591182},
journal = {Molecular Neurobiology},
keywords = {peer review},
month = {jun},
number = {6},
pages = {2766--2798},
pmid = {32356172},
publisher = {Springer},
title = {{Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation}},
url = {https://doi.org/10.1007/s12035-020-01907-4},
volume = {57},
year = {2020}
}

@article{Fernandez-Garcia2020,
abstract = {Background: Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington's disease (HD), the cortico-striatal networks, involved in motor function processing, are the most compromised neural substrate. However, whether the network alterations are intrinsic of the striatum or the cortex is not fully understood. Results: In order to identify early HD neural deficits, we characterized neuronal ensemble calcium activity and network topology of HD striatal and cortical cultures. We used large-scale calcium imaging combined with activity-based network inference analysis. We extracted collective activity events and inferred the topology of the neuronal network in cortical and striatal primary cultures from wild-type and R6/1 mouse model of HD. Striatal, but not cortical, HD networks displayed lower activity and a lessened ability to integrate information. GABAA receptor blockade in healthy and HD striatal cultures generated similar coordinated ensemble activity and network topology, highlighting that the excitatory component of striatal system is spared in HD. Conversely, NMDA receptor activation increased individual neuronal activity while coordinated activity became highly variable and undefined. Interestingly, by boosting NMDA activity, we rectified striatal HD network alterations. Conclusions: Overall, our integrative approach highlights striatal defective network integration capacity as a major contributor of basal ganglia dysfunction in HD and suggests that increased excitatory drive may serve as a potential intervention. In addition, our work provides a valuable tool to evaluate in vitro network recovery after treatment intervention in basal ganglia disorders.},
author = {Fern{\'{a}}ndez-Garc{\'{i}}a, S. and Orlandi, J. G. and {Garc{\'{i}}a-D{\'{i}}az Barriga}, G. A. and Rodr{\'{i}}guez, M. J. and Masana, M. and Soriano, J. and Alberch, J.},
doi = {10.1186/s12915-020-00794-4},
file = {::},
issn = {17417007},
journal = {BMC Biology},
keywords = {peer review,selected},
month = {may},
number = {1},
pages = {58},
pmid = {32466798},
publisher = {BioMed Central Ltd.},
title = {{Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease}},
url = {https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-00794-4},
volume = {18},
year = {2020}
}

Unraveling the hidden complexity of quasideterministic ratchets: Random walks, graphs, and circle maps
Blanch-Mercader, C., Orlandi, J.G., and Casademunt, J.
Physical review e, vol. 101, iss.1, p. 12203, 2020.
[Bibtex]

@article{Blanch-Mercader2020a,
abstract = {Brownian ratchets are shown to feature a nontrivial vanishing-noise limit where the dynamics is reduced to a stochastic alternation between two deterministic circle maps (quasideterministic ratchets). Motivated by cooperative dynamics of molecular motors, here we solve exactly the problem of two interacting quasideterministic ratchets. We show that the dynamics can be described as a random walk on a graph that is specific to each set of parameters. We compute point by point the exact velocity-force V(f) function as a summation over all paths in the specific graph for each f, revealing a complex structure that features self-similarity and nontrivial continuity properties. From a general perspective, we unveil that the alternation of two simple piecewise linear circle maps unfolds a very rich variety of dynamical complexity, in particular the phenomenon of piecewise chaos, where chaos emerges from the combination of nonchaotic maps. We show convergence of the finite-noise case to our exact solution.},
author = {Blanch-Mercader, Carles and Orlandi, Javier G. and Casademunt, Jaume},
doi = {10.1103/PhysRevE.101.012203},
issn = {24700053},
journal = {Physical Review E},
keywords = {peer review},
month = {jan},
number = {1},
pages = {012203},
pmid = {32069660},
publisher = {American Physical Society},
title = {{Unraveling the hidden complexity of quasideterministic ratchets: Random walks, graphs, and circle maps}},
url = {https://link.aps.org/doi/10.1103/PhysRevE.101.012203},
volume = {101},
year = {2020}
}

@article{Blanch-Mercader2020b,
abstract = {Brownian ratchets are shown to feature a nontrivial vanishing-noise limit where the dynamics is reduced to a stochastic alternation between two deterministic circle maps (quasideterministic ratchets). Motivated by cooperative dynamics of molecular motors, here we solve exactly the problem of two interacting quasideterministic ratchets. We show that the dynamics can be described as a random walk on a graph that is specific to each set of parameters. We compute point by point the exact velocity-force V(f) function as a summation over all paths in the specific graph for each f, revealing a complex structure that features self-similarity and nontrivial continuity properties. From a general perspective, we unveil that the alternation of two simple piecewise linear circle maps unfolds a very rich variety of dynamical complexity, in particular the phenomenon of piecewise chaos, where chaos emerges from the combination of nonchaotic maps. We show convergence of the finite-noise case to our exact solution.},
author = {Blanch-Mercader, Carles and Orlandi, Javier G. and Casademunt, Jaume},
doi = {10.1103/PhysRevE.101.012203},
issn = {24700053},
journal = {Physical Review E},
keywords = {peer review},
number = {1},
pages = {1--9},
pmid = {32069660},
publisher = {American Physical Society},
title = {{Unraveling the hidden complexity of quasideterministic ratchets: Random walks, graphs, and circle maps}},
volume = {101},
year = {2020}
}

2018

Neuronal avalanche dynamics indicates different universality classes in neuronal cultures
Yaghoubi, M., de Graaf, T., Orlandi, J.G., Girotto, F., Colicos, M.A., and Davidsen, J.
Scientific reports, vol. 8, iss.1, p. 3417, 2018.
[Bibtex]

@article{Yaghoubi2018,
author = {Yaghoubi, Mohammad and de Graaf, Ty and Orlandi, Javier G. and Girotto, Fernando and Colicos, Michael A. and Davidsen, J{\"{o}}rn},
doi = {10.1038/s41598-018-21730-1},
issn = {2045-2322},
journal = {Scientific Reports},
keywords = {peer review},
month = {dec},
number = {1},
pages = {3417},
title = {{Neuronal avalanche dynamics indicates different universality classes in neuronal cultures}},
url = {http://www.nature.com/articles/s41598-018-21730-1},
volume = {8},
year = {2018}
}

Neuronal spatial arrangement shapes effective connectivity traits of in vitro cortical networks
{Tibau Martorell}, E., Ludl, A.A., Rudiger, S., Orlandi, J.G., and Soriano, J.
Ieee transactions on network science and engineering, vol. early acc, p. 1–1, 2018.
[Bibtex]

@article{Tibau2018,
author = {{Tibau Martorell}, Elisenda and Ludl, Adriaan Alexander and Rudiger, Sten and Orlandi, Javier G. and Soriano, Jordi},
doi = {10.1109/TNSE.2018.2862919},
issn = {2327-4697},
journal = {IEEE Transactions on Network Science and Engineering},
keywords = {peer review},
pages = {1--1},
title = {{Neuronal spatial arrangement shapes effective connectivity traits of in vitro cortical networks}},
url = {https://ieeexplore.ieee.org/document/8424896/},
volume = {early acc},
year = {2018}
}

Stochastic quorum percolation and noise focusing in neuronal networks
Orlandi, J.G. and Casademunt, J.
Physical review e (statistical physics, plasmas, fluids, and related interdisciplinary topics), 2018.
[Bibtex]

@article{Orlandi2018,
author = {Orlandi, Javier G. and Casademunt, Jaume},
journal = {Physical Review E (Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics)},
keywords = {peer review},
title = {{Stochastic quorum percolation and noise focusing in neuronal networks}},
year = {2018}
}

2017

Dominance of Metric Correlations in Two-Dimensional Neuronal Cultures Described through a Random Field Ising Model
Hernández-Navarro, L., Orlandi, J.G., Cerruti, B., Vives, E., and Soriano, J.
Physical review letters, vol. 118, iss.20, p. 208101, 2017.
[Bibtex]

@article{Hernandez-Navarro2017,
author = {Hern{\'{a}}ndez-Navarro, Llu{\'{i}}s and Orlandi, Javier G. and Cerruti, Benedetta and Vives, Eduard and Soriano, Jordi},
doi = {10.1103/PhysRevLett.118.208101},
file = {::},
issn = {0031-9007},
journal = {Physical Review Letters},
keywords = {peer review},
month = {may},
number = {20},
pages = {208101},
title = {{Dominance of Metric Correlations in Two-Dimensional Neuronal Cultures Described through a Random Field Ising Model}},
url = {http://link.aps.org/doi/10.1103/PhysRevLett.118.208101},
volume = {118},
year = {2017}
}

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLC$\gamma$1 pathway
{García-Díaz Barriga}, G., Giralt, A., Anglada-Huguet, M., Gaja-Capdevila, N., Orlandi, J.G., Soriano, J., Canals, J., and Alberch, J.
Human molecular genetics, vol. 26, iss.16, p. 3144–3160, 2017.
[Bibtex]

@article{Garcia-DiazBarriga2017,
abstract = {Huntington's disease (HD) is a fatal neurodegenerative disease with motor, cognitive and psychiatric impairment. Dysfunctions in HD models have been related to reduced levels of striatal brain-derived neurotrophic factor (BDNF) and imbalance between its receptors TrkB and p75(NTR). Thus, molecules with activity on the BDNF/TrkB/p75 system can have therapeutic potential. 7,8-Dihydroxyflavone (7,8-DHF) was described as a TrkB agonist in several models of neuro-degenerative diseases, however, its TrkB activation profile needs further investigation due to its pleiotropic properties and divergence from BDNF effect. To investigate this, we used in vitro and in vivo models of HD to dissect TrkB activation upon 7,8-DHF treatment.7,8-DHF treatment in primary cultures showed phosphorylation of TrkBY816 but not TrkBY515 with activation of the PLC$\gamma$1 pathway leading to morphological and functional improvements. Chronic administration of 7,8-DHF delayed motor deficits in R6/1 mice and reversed deficits on the Novel Object Recognition Test (NORT) at 17 weeks. Morphological and biochemical analyses revealed improved striatal levels of enkephalin, and prevention of striatal volume loss. We found a TrkBY816 but not TrkBY515 phosphorylation recovery in striatum concordant with in vitro results. Additionally, 7,8-DHF normalized striatal levels of induced and neuronal nitric oxide synthase (iNOS and nNOS, respectively) and ameliorated the imbalance of p75/TrkB. Our results provide new insights into the mechanism of action of 7,8-DHF suggesting that its effect through the TrkB receptor in striatum is via selective phosphorylation of its Y816 residue and activation of PLC$\gamma$1 pathway, but pleiotropic effects of the drug also contribute to its therapeutic potential.},
author = {{Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Giralt, Albert and Anglada-Huguet, Marta and Gaja-Capdevila, Nuria and Orlandi, Javier G. and Soriano, Jordi and Canals, Josep-Maria and Alberch, Jordi},
doi = {10.1093/hmg/ddx198},
file = {::},
issn = {0964-6906},
journal = {Human Molecular Genetics},
keywords = {peer review},
month = {may},
number = {16},
pages = {3144--3160},
pmid = {28541476},
title = {{7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLC$\gamma$1 pathway}},
url = {https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddx198 http://www.ncbi.nlm.nih.gov/pubmed/28541476},
volume = {26},
year = {2017}
}

Noise focusing in neuronal tissues: Symmetry breaking and localization in excitable networks with quenched disorder
Orlandi, J.G. and Casademunt, J.
Physical review e, vol. 95, iss.5, p. 52304, 2017.
[Bibtex]

@article{Orlandi2017,
author = {Orlandi, Javier G. and Casademunt, Jaume},
doi = {10.1103/PhysRevE.95.052304},
file = {::},
issn = {2470-0045},
journal = {Physical Review E},
keywords = {peer review},
month = {may},
number = {5},
pages = {052304},
title = {{Noise focusing in neuronal tissues: Symmetry breaking and localization in excitable networks with quenched disorder}},
url = {http://link.aps.org/doi/10.1103/PhysRevE.95.052304},
volume = {95},
year = {2017}
}

2015

@article{Orlandi2015,
author = {Orlandi, Javier G. and Ray, Bisakha and Battaglia, Demian and Guyon, Isabelle and Lemaire, Vincent and Saeed, Mehreen and Soriano, Jordi and Statnikov, Alexander and Stetter, Olav},
journal = {Journal of Machine Learning: Workshop and Conference Proceedings},
keywords = {peer review,selected},
month = {oct},
pages = {1--22},
title = {{First connectomics challenge: from imaging to connectivity}},
url = {http://jmlr.org/proceedings/papers/v46/orlandi15.html},
volume = {46},
year = {2015}
}

Activity and High-Order Effective Connectivity Alterations in Sanfilippo C Patient-Specific Neuronal Networks
Canals, I., Soriano, J., Orlandi, J.G., Torrent, R., Richaud-Patin, Y., Jiménez-Delgado, S., Merlin, S., Follenzi, A., Consiglio, A., Vilageliu, L., Grinberg, D., and Raya, A.
Stem cell reports, vol. 5, iss.4, p. 546–557, 2015.
[Bibtex]

@article{Canals2015,
abstract = {Induced pluripotent stem cell (iPSC) technology has been successfully used to recapitulate phenotypic traits of several human diseases in vitro. Patient-specific iPSC-based disease models are also expected to reveal early functional phenotypes, although this remains to be proved. Here, we generated iPSC lines from two patients with Sanfilippo type C syndrome, a lysosomal storage disorder with inheritable progressive neurodegeneration. Mature neurons obtained from patient-specific iPSC lines recapitulated the main known phenotypes of the disease, not present in genetically corrected patient-specific iPSC-derived cultures. Moreover, neuronal networks organized in vitro from mature patient-derived neurons showed early defects in neuronal activity, network-wide degradation, and altered effective connectivity. Our findings establish the importance of iPSC-based technology to identify early functional phenotypes, which can in turn shed light on the pathological mechanisms occurring in Sanfilippo syndrome. This technology also has the potential to provide valuable readouts to screen compounds, which can prevent the onset of neurodegeneration.},
author = {Canals, Isaac and Soriano, Jordi and Orlandi, Javier G. and Torrent, Roger and Richaud-Patin, Yvonne and Jim{\'{e}}nez-Delgado, Senda and Merlin, Simone and Follenzi, Antonia and Consiglio, Antonella and Vilageliu, Llu{\"{i}}sa and Grinberg, Daniel and Raya, Angel},
doi = {10.1016/j.stemcr.2015.08.016},
file = {::;::;::;::},
isbn = {2213-6711 (Electronic)\r2213-6711 (Linking)},
issn = {22136711},
journal = {Stem Cell Reports},
keywords = {peer review},
month = {oct},
number = {4},
pages = {546--557},
pmid = {26411903},
title = {{Activity and High-Order Effective Connectivity Alterations in Sanfilippo C Patient-Specific Neuronal Networks}},
url = {http://linkinghub.elsevier.com/retrieve/pii/S2213671115002507},
volume = {5},
year = {2015}
}

2014

@article{Orlandi2014a,
abstract = {Neuronal dynamics are fundamentally constrained by the underlying structural network architecture, yet much of the details of this synaptic connectivity are still unknown even in neuronal cultures in vitro. Here we extend a previous approach based on information theory, the Generalized Transfer Entropy, to the reconstruction of connectivity of simulated neuronal networks of both excitatory and inhibitory neurons. We show that, due to the model-free nature of the developed measure, both kinds of connections can be reliably inferred if the average firing rate between synchronous burst events exceeds a small minimum frequency. Furthermore, we suggest, based on systematic simulations, that even lower spontaneous inter-burst rates could be raised to meet the requirements of our reconstruction algorithm by applying a weak spatially homogeneous stimulation to the entire network. By combining multiple recordings of the same in silico network before and after pharmacologically blocking inhibitory synaptic transmission, we show then how it becomes possible to infer with high confidence the excitatory or inhibitory nature of each individual neuron.},
archivePrefix = {arXiv},
arxivId = {1309.4287},
author = {Orlandi, Javier G. and Stetter, Olav and Soriano, Jordi and Geisel, Theo and Battaglia, Demian},
doi = {10.1371/journal.pone.0098842},
editor = {Garcia-Ojalvo, Jordi},
eprint = {1309.4287},
file = {::},
isbn = {1932-6203 (Electronic)\r1932-6203 (Linking)},
issn = {1932-6203},
journal = {PLoS ONE},
keywords = {external,peer review,selected},
month = {jun},
number = {6},
pages = {e98842},
pmid = {24905689},
title = {{Transfer Entropy Reconstruction and Labeling of Neuronal Connections from Simulated Calcium Imaging}},
url = {http://dx.plos.org/10.1371/journal.pone.0098842 http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2013arXiv1309.4287O&link_type=ABSTRACT},
volume = {9},
year = {2014}
}

2013

@article{Orlandi2013b,
abstract = {At early stages of development, neuronal cultures in vitro spontaneously reach a coherent state of collective firing in a pattern of nearly periodic global bursts. Although understanding the spontaneous activity of neuronal networks is of chief importance in neuroscience, the origin and nature of that pulsation has remained elusive. By combining high-resolution calcium imaging with modelling in silico, we show that this behaviour is controlled by the propagation of waves that nucleate randomly in a set of points that is specific to each culture and is selected by a non-trivial interplay between dynamics and topology. The phenomenon is explained by the noise focusing effect--a strong spatio-temporal localization of the noise dynamics that originates in the complex structure of avalanches of spontaneous activity. Results are relevant to neuronal tissues and to complex networks with integrate-and-fire dynamics and metric correlations, for instance, in rumour spreading on social networks.},
author = {Orlandi, Javier G. and Soriano, Jordi and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume},
doi = {10.1038/nphys2686},
file = {::;::},
isbn = {1745-2473},
issn = {1745-2473},
journal = {Nature Physics},
keywords = {peer review,selected},
month = {jul},
number = {9},
pages = {582--590},
pmid = {1000303108},
publisher = {Nature Publishing Group},
title = {{Noise focusing and the emergence of coherent activity in neuronal cultures}},
url = {http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2013NatPh...9..582O&link_type=ABSTRACT http://www.nonlinear.uni-bayreuth.de/en/index.html http://www.nature.com/doifinder/10.1038/nphys2686},
volume = {9},
year = {2013}
}

2011

Toward a New Model of Scientific Publishing: Discussion and a Proposal
Kravitz, D.J. and Baker, C.I.
Frontiers in computational neuroscience, vol. 5, iss.December, p. 55, 2011.
[Bibtex]

@article{Kravitz:2011hu,
abstract = {The current system of publishing in the biological sciences is notable for its redundancy, inconsistency, sluggishness, and opacity. These problems persist, and grow worse, because the peer review system remains focused on deciding whether or not to publish a paper in a particular journal rather than providing (1) a high-quality evaluation of scientific merit and (2) the information necessary to organize and prioritize the literature. Online access has eliminated the need for journals as distribution channels, so their primary current role is to provide authors with feedback prior to publication and a quick way for other researchers to prioritize the literature based on which journal publishes a paper. However, the feedback provided by reviewers is not focused on scientific merit but on whether to publish in a particular journal, which is generally of little use to authors and an opaque and noisy basis for prioritizing the literature. Further, each submission of a rejected manuscript requires the entire machinery of peer review to creak to life anew. This redundancy incurs delays, inconsistency, and increased burdens on authors, reviewers, and editors. Finally, reviewers have no real incentive to review well or quickly, as their performance is not tracked, let alone rewarded. One of the consistent suggestions for modifying the current peer review system is the introduction of some form of post-publication reception, and the development of a marketplace where the priority of a paper rises and falls based on its reception from the field (see other articles in this special topics). However, the information that accompanies a paper into the marketplace is as important as the marketplace's mechanics. Beyond suggestions concerning the mechanisms of reception, we propose an update to the system of publishing in which publication is guaranteed, but pre-publication peer review still occurs, giving the authors the opportunity to revise their work following a mini pre-reception from the field. This step also provides a consistent set of rankings and reviews to the marketplace, allowing for early prioritization and stabilizing its early dynamics. We further propose to improve the general quality of reviewing by providing tangible rewards to those who do it well.},
author = {Kravitz, Dwight J. and Baker, Chris I.},
doi = {10.3389/fncom.2011.00055},
file = {::},
isbn = {1662-5188 (Electronic)\r1662-5188 (Linking)},
issn = {1662-5188},
journal = {Frontiers in Computational Neuroscience},
keywords = {neuroscience,peer review,publishing},
number = {December},
pages = {55},
pmid = {22164143},
title = {{Toward a New Model of Scientific Publishing: Discussion and a Proposal}},
url = {http://journal.frontiersin.org/article/10.3389/fncom.2011.00055/abstract},
volume = {5},
year = {2011}
}

2010

Cooperativity of self-organized Brownian motors pulling on soft cargoes
Orlandi, J.G., Blanch-Mercader, C., Brugués, J., and Casademunt, J.
Physical review. e, statistical, nonlinear, and soft matter physics, vol. 82, iss.6, p. 61903, 2010.
[Bibtex]

@article{Orlandi2010b,
abstract = {We study the cooperative dynamics of Brownian motors moving along a one-dimensional track when an external load is applied to the leading motor, mimicking molecular motors pulling on membrane-bound cargoes in intracellular traffic. Due to the asymmetric loading, self-organized motor clusters form spontaneously. We model the motors with a two-state noise-driven ratchet formulation and study analytically and numerically the collective velocity-force and efficiency-force curves resulting from mutual interactions, mostly hard-core repulsion and weak (nonbinding) attraction. We analyze different parameter regimes including the limits of weak noise, mean-field behavior, rigid coupling, and large numbers of motors, for the different interactions. We present a general framework to classify and quantify cooperativity. We show that asymmetric loading leads generically to enhanced cooperativity beyond the simple superposition of the effects of individual motors. For weakly attracting interactions, the cooperativity is mostly enhanced, including highly coordinated motion of motors and complex nonmonotonic velocity-force curves, leading to self-regulated clusters. The dynamical scenario is enriched by resonances associated to commensurability of different length scales. Large clusters exhibit synchronized dynamics and bidirectional motion. Biological implications are discussed.},
annote = {From Duplicate 2 (Cooperativity of self-organized Brownian motors pulling on soft cargoes - Orlandi, Javier G; Blanch-Mercader, Carles; Brugu{\'{e}}s, Jan; Casademunt, Jaume)
AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Javier G. Orlandi; Carles Blanch-Mercader; Jan Brugu{{\'{e}}}s; Jaume Casademunt},
author = {Orlandi, Javier G. and Blanch-Mercader, Carles and Brugu{\'{e}}s, Jan and Casademunt, Jaume},
doi = {10.1103/PhysRevE.82.061903},
file = {::},
issn = {15393755},
journal = {Physical review. E, Statistical, nonlinear, and soft matter physics},
keywords = {peer review},
month = {dec},
number = {6},
pages = {61903},
pmid = {21230686},
title = {{Cooperativity of self-organized Brownian motors pulling on soft cargoes}},
url = {http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2010PhRvE..82f1903O&link_type=ABSTRACT},
volume = {82},
year = {2010}
}

2009

Theoretical study of a membrane channel gated by ATP
Orlandi, J.G. and Sancho, J.M.
The european physical journal e, vol. 29, iss.3, p. 329–336, 2009.
[Bibtex]

@article{Orlandi2009a,
abstract = {We study channel transport across biomembranes. We propose a model that couples the diffusive dynamics with the gating process via a two-state ratchet mechanism. This gating process is governed by ATP binding and hydrolysis, and the process exhibits Michaelis-Menten enzymatic kinetics. The particle flow and permeability of the channel are studied both analytically and numerically in the steady-state regime, while working between fixed concentrations. The results are compared with simpler models and with experimental data. Also, a simulation framework, that allows high flexibility in parameter exploration, is introduced.},
annote = {From Duplicate 1 (Theoretical study of a membrane channel gated by ATP - Orlandi, Javier G; Sancho, Jose Maria)
AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Javier G. Orlandi; Jose M. Sancho},
author = {Orlandi, Javier G. and Sancho, Jose Maria},
doi = {10.1140/epje/i2009-10483-9},
file = {::},
issn = {1292-8941},
journal = {The European Physical Journal E},
keywords = {peer review},
month = {jul},
number = {3},
pages = {329--336},
pmid = {19575251},
title = {{Theoretical study of a membrane channel gated by ATP}},
url = {http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009EPJE...29..329O&link_type=ABSTRACT http://www.springerlink.com/index/10.1140/epje/i2009-10483-9},
volume = {29},
year = {2009}
}

Other peer-reviewed publications

Experimental approaches to assess connectivity in living neuronal networks
Hernández-Navarro, L., Orlandi, J.G., Casademunt, J., and Soriano, J., ,” in Artificial neural networks and machine learning – icann 2016, Springer international publishing, 2016, vol. 9886 LNCS.
[Bibtex]

@incollection{Hernandez-Navarro2016,
abstract = {{\textcopyright} Springer International Publishing Switzerland 2016. The complexity of the connectivity blueprint in living neuronal circuits has motivated the development of theoretical and computational tools to infer their major characteristics. Three major descriptors are of interest, namely the average number of connections, the distribution of connections, and high-order topological features such as clustering. In our study we have explored them by analyzing the activity in neuronal cultures, and considered approaches that include the analysis of the network as a dynamical system, percolation, and spin models. For the first approach, we recorded spontaneous neuronal activity and resolved the ignition times of all the monitored neurons. The analysis shows that activity takes place in the form of bursts, events of fast activation of all the neurons in a short time window. These bursts occur quasi-periodically along time and initiate in a few, well-defined locations in the culture, which we call nucleation points [1] . The number of nucleation points, as well as the characterisitics of the propagating fronts, strongly depend on the circuitry of the network. Hence, by carrying out experiments with different perturbations of the neuronal circuitry (e.g. by chemical or electrical action), we can extract interesting properties of the underlying connectivity map. For the second and third approaches, we considered a global bath excitation protocol combined with a progressive weakening of the connections among neurons [2]. This protocol leads to a percolative scenario, in which the largest group of connected neurons defines a giant component that decreases in size as the network is gradually disconnected. At a critical disconnection degree, the giant component disappears. The properties of this critical point are tightly related with the topology of the circuit, particularly the average number of connections.},
author = {Hern{\'{a}}ndez-Navarro, L. and Orlandi, Javier G. and Casademunt, J. and Soriano, J.},
booktitle = {Artificial Neural Networks and Machine Learning – ICANN 2016},
isbn = {9783319447773},
issn = {16113349},
keywords = {other},
publisher = {Springer International Publishing},
title = {{Experimental approaches to assess connectivity in living neuronal networks}},
volume = {9886 LNCS},
year = {2016}
}

The emergence of spontaneous activity in neuronal cultures
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Soriano, J., and Casademunt, J.
American institute of physics: conference proceedings, vol. 1510, iss.25, p. 25–27, 2013.
[Bibtex]

@article{Orlandi2013,
abstract = {In vitro neuronal networks of dissociated hippocampal or cortical tissues are one of the most attractive model systems for the physics and neuroscience communities. Cultured neurons grow and mature, develop axons and dendrites, and quickly connect to their neighbors to establish a spontaneously active network within a week. The resulting neuronal network is characterized by a combination of excitatory and inhibitory neurons coupled through synaptic connections that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons' spiking activity and synaptic transmission, together with biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including the emergence and maintenance of periodic spontaneous activity, avalanches, propagation of fronts and synchronization. In this work we present an overview on the rich activity of cultured neuronal networks, and detail the minimal theoretical considerations needed to describe experimental observations.},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
doi = {10.1063/1.4776497},
file = {::},
isbn = {9780735411289},
issn = {15517616},
journal = {American Institute of Physics: Conference Proceedings},
keywords = {other},
month = {jan},
number = {25},
pages = {25--27},
pmid = {1000303108},
title = {{The emergence of spontaneous activity in neuronal cultures}},
url = {http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2013AIPC.1510...25O&link_type=ABSTRACT},
volume = {1510},
year = {2013}
}

The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Casademunt, J., Soriano, J., and Casademunt, J.
Nolta 2012 international symposium on nonlinear theory and its applications, vol. 1, p. 547–550, 2012.
[Bibtex]

@article{Orlandi2012,
address = {Mallorca, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume and Soriano, Jordi and Casademunt, Jaume},
doi = {10.15248/proc.1.547},
file = {::},
issn = {2188-5079},
journal = {NOLTA 2012 International Symposium on Nonlinear Theory and its Applications},
keywords = {other,talk},
month = {oct},
pages = {547--550},
title = {{The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks}},
url = {http://javierorlandi.com/?p=108 http://www.proceeding.ieice.org/summary.php?id=p1_0_547&year=},
volume = {1},
year = {2012}
}

Software

@misc{Orlandi2017b,
author = {Orlandi, Javier G. and Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and Comella-Bolla, Andrea and Masana, Merc{\`{e}} and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Yaghoubi, Mohammad and Kipp, Alexander and Canals, Josep M. and Colicos, Michael A. and Davidsen, J{\"{o}}rn and Alberch, Jordi and Soriano, Jordi},
doi = {doi.org/10.5281/zenodo.1119025},
keywords = {selected,software},
publisher = {Zenodo research data repository},
title = {{NETCAL: An interactive platform for large-scale, NETwork and population dynamics analysis of CALcium imaging recordings}},
url = {http://www.itsnetcal.com},
year = {2017}
}

Books

Neural Connectomics Challenge
Battaglia, D., Guyon, I., Lemaire, V., Orlandi, J.G., Ray, B., and Soriano, J., , Battaglia, D., Guyon, I., Lemaire, V., Orlandi, J., Ray, B., and Soriano, J., Eds., Cham: Springer international publishing, 2017.
[Bibtex]

@book{Battaglia2017,
address = {Cham},
author = {Battaglia, Demian and Guyon, Isabelle and Lemaire, Vincent and Orlandi, Javier G. and Ray, Bisakha and Soriano, Jordi},
doi = {10.1007/978-3-319-53070-3},
editor = {Battaglia, Demian and Guyon, Isabelle and Lemaire, Vincent and Orlandi, Javier and Ray, Bisakha and Soriano, Jordi},
file = {::},
isbn = {978-3-319-53069-7},
keywords = {book},
publisher = {Springer International Publishing},
series = {The Springer Series on Challenges in Machine Learning},
title = {{Neural Connectomics Challenge}},
url = {http://link.springer.com/10.1007/978-3-319-53070-3},
year = {2017}
}

Invited talks

Network interactions in the mouse visual cortex are predictive of perceptual decisions
Orlandi, J.G.
8th riec int. symp. brain funct. brain comput., Sendai, Japan, 2020.
[Bibtex]

@inproceedings{Orlandi2020ra,
address = {Sendai, Japan},
author = {Orlandi, Javier G},
booktitle = {8th RIEC Int. Symp. Brain Funct. Brain Comput.},
keywords = {invited talk},
title = {{Network interactions in the mouse visual cortex are predictive of perceptual decisions}},
url = {http://www.tfc.tohoku.ac.jp/event/4249.html},
year = {2020}
}

Detecting neuron-glia communication through optic flow and synaptic stabilization in neuronal cultures
Orlandi, J.G.
The 7th riec international symposium on brain functions and brain computer, Sendai, Japan, 2019.
[Bibtex]

@inproceedings{Orlandi2019aa,
address = {Sendai, Japan},
author = {Orlandi, Javier G.},
booktitle = {The 7th RIEC International Symposium on Brain Functions and Brain Computer},
keywords = {invited talk},
title = {{Detecting neuron-glia communication through optic flow and synaptic stabilization in neuronal cultures}},
url = {http://www.nanospin.riec.tohoku.ac.jp/RIEC_Sympo/index.html},
year = {2019}
}

Emergent behaviour in neuronal cultures
Orlandi, J.G.
International symposium on complexity science approaches to brain dynamics, Calgary, Canada, 2018.
[Bibtex]

@inproceedings{Orlandi2018e,
address = {Calgary, Canada},
author = {Orlandi, Javier G.},
booktitle = {International Symposium on Complexity Science Approaches to Brain Dynamics},
keywords = {invited talk},
title = {{Emergent behaviour in neuronal cultures}},
url = {https://www.ucalgary.ca/complexity/symposium/presentations},
year = {2018}
}

Emergent behaviour in Neuronal Cultures. From activity to connectivity and back
Orlandi, J.G.
Riken center for brain science, Wakoshi, Japan, 2018.
[Bibtex]

@inproceedings{Orlandi2017c,
address = {Wakoshi, Japan},
author = {Orlandi, Javier G.},
booktitle = {RIKEN Center for Brain Science},
keywords = {invited talk},
title = {{Emergent behaviour in Neuronal Cultures. From activity to connectivity and back}},
year = {2018}
}

Inferring structural and functional neuronal networks from calcium imaging recordings
Orlandi, J.G.
Instituto de neurociencias de alicante, Alicante, Spain, 2017.
[Bibtex]

@inproceedings{Orlandi2017c,
address = {Alicante, Spain},
author = {Orlandi, Javier G.},
booktitle = {Instituto de Neurociencias de Alicante},
keywords = {invited talk},
title = {{Inferring structural and functional neuronal networks from calcium imaging recordings}},
url = {http://in.umh-csic.es/seminarios.aspx},
year = {2017}
}

Noise focusing and the emergence of coherent activity in neuronal cultures
Orlandi, J.G.
Complexity science seminar, university of calgary, Calgary, Canada, 2016.
[Bibtex]

@inproceedings{Orlandi2016,
address = {Calgary, Canada},
author = {Orlandi, Javier G.},
booktitle = {Complexity Science Seminar, University of Calgary},
keywords = {invited talk},
title = {{Noise focusing and the emergence of coherent activity in neuronal cultures}},
url = {http://www.ucalgary.ca/complexity/events},
year = {2016}
}

First connectomics challenge in neuronal cultures. Crowdsourcing network reconstruction
Orlandi, J.G.
Connectome workbench, university of cambridge, Cambridge, United Kingdom, 2015.
[Bibtex]

@inproceedings{Orlandi2015a,
abstract = {We have recently run a crowdsourcing challenge to reverse engineer the structure of neuronal networks from the analysis of spontaneous activity in neuronal cultures. Unraveling the connectivity of neuronal circuits involving large numbers of neurons is one of the major challenges neuroscience faces today. Indeed, important advances in the last decade have provided unprecedented level of detail on the structure and function of these circuits. However, the understanding of inter-relations between the observed functional couplings and the underlying neuronal dynamics and circuit structure is still a major problem. Highly controllable experimental platforms, in which results and predictions of different functional connectivity analysis techniques can be reliably tested are needed, and neuronal cultures are inherently good candidates. Based on our experimental studies in the dynamics of neuronal cultures and network inference techniques, we launched a challenge in the form of an online competition to foster the development of novel connectivity-from-activity inference algorithms, specially targeted to researchers in other disciplines. We generated calcium fluorescence traces from simulated neuronal cultures of different topologies and dynamics and provided the participants with different benchmarks and sample datasets to test their algorithms and predictions on the underlying network structure. Participants were ranked based on the achieved performance against selected competition network instances, without any knowledge of the underlying connectivity. At the end of the challenge, several participants were able to outperform state of the art algorithms, and even reach outstanding reconstructions. Most of the code developed by the participants was released open-source after extensive post-challenge validations and verifications. This allowed us to gather a rich suite of highly diverse algorithms and techniques for network reconstruction, thanks to the collaboration between usually segregated research communities.},
address = {Cambridge, United Kingdom},
author = {Orlandi, Javier G.},
booktitle = {Connectome Workbench, University of Cambridge},
keywords = {invited talk},
month = {sep},
title = {{First connectomics challenge in neuronal cultures. Crowdsourcing network reconstruction}},
url = {http://www.neuroscience.cam.ac.uk/events/event.php?permalink=728b19b922},
year = {2015}
}

Contributed talks

Network inference in neuroscience with Causal Deep Learning
Orlandi, J.G.
Iccs 2018 – 9th international conference on complex systems, Boston, MA, 2018.
[Bibtex]

@inproceedings{Orlandi2018g,
address = {Boston, MA},
author = {Orlandi, Javier G.},
booktitle = {ICCS 2018 - 9th International Conference on Complex Systems},
keywords = {talk},
title = {{Network inference in neuroscience with Causal Deep Learning}},
url = {http://www.necsi.edu/events/iccs2018/},
year = {2018}
}

Neuronal avalanche dynamics leading to diverse universality classes in neuronal cultures
Orlandi, J.G.
Iccs 2018 – 9th international conference on complex systems, Boston, MA, 2018.
[Bibtex]

@inproceedings{Orlandi2018a,
address = {Boston, MA},
author = {Orlandi, Javier G.},
booktitle = {ICCS 2018 - 9th International Conference on Complex Systems},
keywords = {talk},
title = {{Neuronal avalanche dynamics leading to diverse universality classes in neuronal cultures}},
url = {http://www.necsi.edu/events/iccs2018/},
year = {2018}
}

Transfer entropy reconstruction of neuronal networks from calcium imaging data
Orlandi, J.G.
Causality, information transfer and dynamical networks, Dresden, Germany, 2014.
[Bibtex]

@inproceedings{Orlandi2014c,
address = {Dresden, Germany},
author = {Orlandi, Javier G.},
booktitle = {Causality, Information Transfer and Dynamical Networks},
keywords = {talk},
month = {jun},
title = {{Transfer entropy reconstruction of neuronal networks from calcium imaging data}},
url = {http://www.mpipks-dresden.mpg.de/$\sim$cidnet14/},
year = {2014}
}

Noise focusing: unfolding coherent activity in neuronal cultures
Orlandi, J.G.
Anacapri workshop – the brain: criticality, dynamics, networks and function, Anacapri, Italy, 2013.
[Bibtex]

@inproceedings{Orlandi2013c,
address = {Anacapri, Italy},
author = {Orlandi, Javier G.},
booktitle = {Anacapri Workshop - The Brain: Criticality, Dynamics, Networks and Function},
keywords = {talk},
month = {sep},
title = {{Noise focusing: unfolding coherent activity in neuronal cultures}},
url = {http://brain-capri.fisica.unisa.it/},
year = {2013}
}

The emergence of spontaneous activity in neuronal cultures, coherence from noise
Orlandi, J.G., Soriano, J., Alvarez-Lacalle, E., Teller, S., Casademunt, J., Soriano, J., and Casademunt, J.
Cns 2013, 22nd anual computational neuroscience meeting, Barcelona, Spain, 2013, p. 25–27.
[Bibtex]

@inproceedings{Orlandi2013a,
abstract = {In vitro neuronal networks of dissociated hippocampal or cortical tissues are one of the most attractive model systems for the physics and neuroscience communities. Cultured neurons grow and mature, develop axons and dendrites, and quickly connect to their neighbors to establish a spontaneously active network within a week. The resulting neuronal network is characterized by a combination of excitatory and inhibitory neurons coupled through synaptic connections that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons' spiking activity and synaptic transmission, together with biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including the emergence and maintenance of periodic spontaneous activity, avalanches, propagation of fronts and synchronization. In this work we present an overview on the rich activity of cultured neuronal networks, and detail the minimal theoretical considerations needed to describe experimental observations.},
address = {Barcelona, Spain},
annote = {From Duplicate 3 (The emergence of spontaneous activity in neuronal cultures, coherence from noise - Orlandi, Javier G; Soriano, Jordi; Alvarez-Lacalle, Enrique; Teller, Sara; Casademunt, Jaume)
AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Orlandi, J.G.; Alvarez-Lacalle, E.; Teller S.; Soriano, J; Casademunt, J.},
author = {Orlandi, Javier G. and Soriano, Jordi and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume and Soriano, Jordi and Casademunt, Jaume},
booktitle = {CNS 2013, 22nd Anual Computational Neuroscience Meeting},
doi = {10.1186/1471-2202-14-S1-P54},
file = {::},
isbn = {9780735411289},
issn = {15517616},
keywords = {neuronal cultures,poster,spontaneous activity,talk},
month = {feb},
number = {Suppl 1},
pages = {25--27},
pmid = {1000303108},
publisher = {BioMed Central Ltd},
title = {{The emergence of spontaneous activity in neuronal cultures, coherence from noise}},
url = {http://www.crm.cat/en/Activities/Pages/ActivityFoldersAndPages/Curs 2012-2013/BARCSYN2013/BARCSYN2013.aspx http://www.biomedcentral.com/1471-2202/14/S1/P54},
volume = {1510},
year = {2013}
}

The emergence of coherent activity in living neuronal networks
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Soriano, J., and Casademunt, J.
Fises ’12 xviii congreso de física estadística, Palma de Mallorca, Spain, 2012.
[Bibtex]

@inproceedings{Orlandi2012a,
address = {Palma de Mallorca, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
booktitle = {FisEs '12 XVIII Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {talk},
month = {oct},
title = {{The emergence of coherent activity in living neuronal networks}},
url = {http://www.gefenol.es/FisEs/12/},
year = {2012}
}

@article{Orlandi2012,
address = {Mallorca, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume and Soriano, Jordi and Casademunt, Jaume},
doi = {10.15248/proc.1.547},
file = {::},
issn = {2188-5079},
journal = {NOLTA 2012 International Symposium on Nonlinear Theory and its Applications},
keywords = {other,talk},
month = {oct},
pages = {547--550},
title = {{The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks}},
url = {http://javierorlandi.com/?p=108 http://www.proceeding.ieice.org/summary.php?id=p1_0_547&year=},
volume = {1},
year = {2012}
}

The emergence of spontaneous activity in neuronal cultures
Orlandi, J.G.
Physics, computation, and the mind – advances and challenges at interfaces, La Herradura, Spain, 2012.
[Bibtex]

@inproceedings{Orlandi2012c,
address = {La Herradura, Spain},
author = {Orlandi, Javier G.},
booktitle = {Physics, Computation, and the Mind - Advances and Challenges at Interfaces},
keywords = {talk},
month = {sep},
title = {{The emergence of spontaneous activity in neuronal cultures}},
url = {http://ergodic.ugr.es/cp/pasteditions/12/},
year = {2012}
}

Neuronal Cultures: Synchronization, Forcing, and the Mechanisms behind Spontaneous Activity
Orlandi, J.G.
Ibersinc: red sobre dinámica y sincronización en redes, Barcelona, Spain, 2011.
[Bibtex]

@inproceedings{Orlandi2011,
address = {Barcelona, Spain},
author = {Orlandi, Javier G.},
booktitle = {IBERSINC: Red sobre Din{\'{a}}mica y Sincronizaci{\'{o}}n en Redes},
keywords = {talk},
month = {mar},
title = {{Neuronal Cultures: Synchronization, Forcing, and the Mechanisms behind Spontaneous Activity}},
year = {2011}
}

Unraveling Spontaneous Activity in Neuronal Cultures
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Soriano, J., and Casademunt, J.
Barcsyn: 2011 barcelona computational and systems neuroscience meeting, Barcelona, Spain, 2011.
[Bibtex]

@inproceedings{Orlandi2011b,
address = {Barcelona, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
booktitle = {BARCSYN: 2011 Barcelona Computational and Systems Neuroscience Meeting},
keywords = {poster,talk},
month = {feb},
title = {{Unraveling Spontaneous Activity in Neuronal Cultures}},
url = {http://www.crm.cat/en/Activities/Pages/ActivityFoldersAndPages/Curs 2011-2012/BARCSYN2011/default.aspx},
year = {2011}
}

Posters and other conference contributions

Network interactions in the mouse visual cortex are predictive of perceptual decisions
Orlandi, J.G., Grzelkowski, S., Abdolrahmani, M., Aoki, R., Lyamzin, D.R., and Benucci, A.
Soc. neurosci. sfn 2019, Chicago, USA, 2019.
[Bibtex]

@inproceedings{Orlandi2019cc,
address = {Chicago, USA},
author = {Orlandi, Javier G. and Grzelkowski, Stephan and Abdolrahmani, Mohammad and Aoki, Ryo and Lyamzin, Dmitry R and Benucci, Andrea},
booktitle = {Soc. Neurosci. SFN 2019},
keywords = {poster},
month = {nov},
title = {{Network interactions in the mouse visual cortex are predictive of perceptual decisions}},
year = {2019}
}

Functional connectivity and dynamics in Huntington’s disease striatal cultures revealed through large-scale calcium imaging
Fernández-García, S., Masana, M., Orlandi, J.G., {García-Díaz Barriga}, G., Soriano, J., and Alberch, J.
Neuroscience 2017, Washington DC, USA, 2017.
[Bibtex]

@inproceedings{Fernandez-Garcia2017,
address = {Washington DC, USA},
author = {Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and Masana, Merc{\`{e}} and Orlandi, Javier G. and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Soriano, Jordi and Alberch, Jordi},
booktitle = {Neuroscience 2017},
keywords = {abstract,poster},
title = {{Functional connectivity and dynamics in Huntington's disease striatal cultures revealed through large-scale calcium imaging}},
url = {http://www.abstractsonline.com/pp8/#!/4376/presentation/27525},
year = {2017}
}

NETCAL: An interactive platform for large-scale, NETwork and population dynamics analysis of CALcium imaging recordings
Orlandi, J.G., Fernández-García, S., Comella-Bolla, A., Masana, M., {García-Díaz Barriga}, G., Yaghoobi, M., Canals, J., Colicos, M.A., Davidsen, J., Alberch, J., and Soriano, J.
Neuroscience 2017, Washington DC, USA, 2017.
[Bibtex]

@inproceedings{Orlandi2017a,
address = {Washington DC, USA},
author = {Orlandi, Javier G. and Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and Comella-Bolla, Andrea and Masana, Merc{\`{e}} and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Yaghoobi, Mohammad and Canals, Josep-Maria and Colicos, Michael A. and Davidsen, J{\"{o}}rn and Alberch, Jordi and Soriano, Jordi},
booktitle = {Neuroscience 2017},
keywords = {abstract,poster},
title = {{NETCAL: An interactive platform for large-scale, NETwork and population dynamics analysis of CALcium imaging recordings}},
url = {http://www.abstractsonline.com/pp8/#!/4376/presentation/26602},
year = {2017}
}

Altered functional activity in vmDA neurons derived from Parkinson’s disease-induced pluripotent stem cells (iPSC)
Carola, G., Puxan, B.N., Orlandi, J.G., Faella, A., Soriano, J., Raya, A., and Consiglio, A.
Human gene therapy 2016, 2016.
[Bibtex]

@inproceedings{Carola2016,
author = {Carola, G and Puxan, Bayo N and Orlandi, Javier G. and Faella, A and Soriano, J and Raya, A and Consiglio, A},
booktitle = {Human Gene Therapy 2016},
keywords = {poster},
title = {{Altered functional activity in vmDA neurons derived from Parkinson's disease-induced pluripotent stem cells (iPSC)}},
volume = {27},
year = {2016}
}

First connectomics challenge: fostering research in network inference and its applications
Orlandi, J.G., Battaglia, D., Stetter, O., Canals, I., Guyon, I., Ray, B., Saeed, M., and Soriano, J.
10th fens forum of neuroscience, Copenhagen, Denmark, 2016.
[Bibtex]

@inproceedings{Orlandi2016b,
address = {Copenhagen, Denmark},
author = {Orlandi, Javier G. and Battaglia, Demian and Stetter, Olav and Canals, Isaac and Guyon, Isabelle and Ray, Bisakha and Saeed, Mehreen and Soriano, Jordi},
booktitle = {10th FENS Forum of Neuroscience},
keywords = {poster},
title = {{First connectomics challenge: fostering research in network inference and its applications}},
url = {http://forum2016.fens.org/},
year = {2016}
}

Deciphering Huntington’s disease striatal network dynamics using high-speed high-resolution calcium imaging
Fernández-García, S., Masana, M., Orlandi, J.G., {García-Díaz Barriga}, G., Soriano, J., and Alberch, J.
10th fens forum of neuroscience, Copenhagen, Denmark, 2016.
[Bibtex]

@inproceedings{Fernandez-Garcia2016,
address = {Copenhagen, Denmark},
author = {Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and Masana, Merc{\`{e}} and Orlandi, Javier G. and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Soriano, Jordi and Alberch, Jordi},
booktitle = {10th FENS Forum of Neuroscience},
keywords = {poster},
title = {{Deciphering Huntington's disease striatal network dynamics using high-speed high-resolution calcium imaging}},
url = {http://forum2016.fens.org/},
year = {2016}
}

Spontaneous activity in cultures with dictated connectivity
Hernández-Navarro, L., Orlandi, J.G., and Soriano, J.
10th fens forum of neuroscience, Copenhagen, Denmark, 2016.
[Bibtex]

@inproceedings{Hernandez-Navarro2016a,
address = {Copenhagen, Denmark},
author = {Hern{\'{a}}ndez-Navarro, Llu{\'{i}}s and Orlandi, Javier G. and Soriano, Jordi},
booktitle = {10th FENS Forum of Neuroscience},
keywords = {poster},
title = {{Spontaneous activity in cultures with dictated connectivity}},
url = {http://forum2016.fens.org/},
year = {2016}
}

Characterization of neuronal network structure and dynamics in striatal cultures
Masana, M., Orlandi, J.G., Fernández-García, S., {García-Díaz Barriga}, G., Alberch, J., and Soriano, J.
10th fens forum of neuroscience, Copenhagen, Denmark, 2016.
[Bibtex]

@inproceedings{Masana2016,
address = {Copenhagen, Denmark},
author = {Masana, Merc{\`{e}} and Orlandi, Javier G. and Fern{\'{a}}ndez-Garc{\'{i}}a, Sara and {Garc{\'{i}}a-D{\'{i}}az Barriga}, Gerardo and Alberch, Jordi and Soriano, Jordi},
booktitle = {10th FENS Forum of Neuroscience},
keywords = {poster},
title = {{Characterization of neuronal network structure and dynamics in striatal cultures}},
url = {http://forum2016.fens.org/},
year = {2016}
}

Differentiation of human iPSC toward postmitotic forebrain neurons achieved a mature phenotype with spontaneous network activity
Comella-Bolla, A., Straccia, M., Miguez, A., Sanders, P., Orlandi, J.G., Bombau, G., Carrere, J., Kemp, P.J., Alberch, J., Soriano, J., Allen, N.D., and Canals, J.M.
10th fens forum of neuroscience, Copenhagen, Denmark, 2016.
[Bibtex]

@inproceedings{Comella-Bolla2016,
address = {Copenhagen, Denmark},
author = {Comella-Bolla, Andrea and Straccia, Marco and Miguez, Andres and Sanders, Phil and Orlandi, Javier G. and Bombau, Georgina and Carrere, Jordi and Kemp, Paul J and Alberch, Jordi and Soriano, Jordi and Allen, Nicholas D and Canals, Josep M},
booktitle = {10th FENS Forum of Neuroscience},
keywords = {poster},
title = {{Differentiation of human iPSC toward postmitotic forebrain neurons achieved a mature phenotype with spontaneous network activity}},
url = {http://forum2016.fens.org/},
year = {2016}
}

First connectomics challenge: fostering research in network inference and its applications
Orlandi, J.G., Battaglia, D., Stetter, O., Canals, I., Guyon, I., Saeed, M., and Soriano, J.
Brain dynamics and statistics: simulation versus data, Banff, Canada, 2016.
[Bibtex]

@inproceedings{Orlandi2016a,
address = {Banff, Canada},
author = {Orlandi, Javier G. and Battaglia, Demian and Stetter, Olav and Canals, Isaac and Guyon, Isabelle and Saeed, Mehreen and Soriano, Jordi},
booktitle = {Brain Dynamics and Statistics: Simulation versus Data},
keywords = {poster},
title = {{First connectomics challenge: fostering research in network inference and its applications}},
url = {https://www.birs.ca/events/2017/5-day-workshops/17w5036},
year = {2016}
}

First neuronal connectomics challenge: From imaging to connectivity: From design to result harvesting and crowdpublishing
Orlandi, J.G., Ray, B., Saeed, M., Soriano, J., Statnikov, A., Stetter, O., Guyon, I., and Battaglia, D.
Society for neuroscience sfn 2014, Washington DC, USA, 2014.
[Bibtex]

@inproceedings{Orlandi2014b,
address = {Washington DC, USA},
author = {Orlandi, Javier G. and Ray, Bisakha and Saeed, Mehreen and Soriano, Jordi and Statnikov, Alexander and Stetter, Olav and Guyon, Isabelle and Battaglia, Demian},
booktitle = {Society for Neuroscience SFN 2014},
keywords = {poster},
month = {nov},
title = {{First neuronal connectomics challenge: From imaging to connectivity: From design to result harvesting and crowdpublishing}},
url = {http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=08eeb24b-e182-4bb9-abc7-14e25e2b17a0&cKey=ad00af7d-0282-4d72-8628-edd850d0fcc0&mKey=%257b54C85D94-6D69-4B09-AFAA-502C0E680CA7%257d},
year = {2014}
}

Design of the first neuronal connectomics challenge: From imaging to connectivity
Guyon, I., Battaglia, D., Guyon, A., Lemaire, V., Orlandi, J.G., Ray, B., Saeed, M., Soriano, J., Statnikov, A., and Stetter, O.
Ieee wcci 2014, Beijing, China, 2014, p. 2600–2607.
[Bibtex]

@inproceedings{Guyon2014,
abstract = {We are organizing a challenge to reverse engineer the structure of neuronal networks from patterns of activity recorded with calcium fluorescence imaging. Unraveling the brain structure at the neuronal level at a large scale is an important step in brain science, with many ramifications in the comprehension of animal and human intelligence and learning capabilities, as well as understanding and curing neuronal diseases and injuries. However, uncovering the anatomy of the brain by disentangling the neural wiring with its very fine and intertwined dendrites and axons, making both local and far reaching synapses, is a very arduous task: traditional methods of axonal tracing are tedious, difficult, and time consuming. This challenge proposes to approach the problem from a different angle, by reconstructing the effective connectivity of a neuronal network from observations of neuronal activity of thousands of neurons, which can be obtained with state-of-the-art fluorescence calcium imaging. To evaluate the effectiveness of proposed algorithms, we will use data obtained with a realistic simulator of real neurons for which we have ground truth of the neuronal connections. We produced simulated calcium imaging data, taking into account a model of fluorescence and light scattering. The task of the participants is to reconstruct a network of 1000 neurons from time series of neuronal activities obtained with this model. This challenge is part of the official selection of the WCCI 2014 competition program. View full abstract},
address = {Beijing, China},
author = {Guyon, Isabelle and Battaglia, Demian and Guyon, Alice and Lemaire, Vincent and Orlandi, Javier G. and Ray, Bisakha and Saeed, Mehreen and Soriano, Jordi and Statnikov, Alexander and Stetter, Olav},
booktitle = {IEEE WCCI 2014},
doi = {10.1109/IJCNN.2014.6889913},
file = {::;::},
isbn = {9781479914845},
issn = {1662-5196},
keywords = {poster},
pages = {2600--2607},
pmid = {6889913},
publisher = {IEEE},
title = {{Design of the first neuronal connectomics challenge: From imaging to connectivity}},
url = {http://javierorlandi.com/?p=245},
year = {2014}
}

Network reconstruction from calcium imaging data of spontaneously bursting neuronal activity
Stetter, O., Orlandi, J.G., Soriano, J., Battaglia, D., and Geisel, T.
Cns 2013, 22nd anual computational neuroscience meeting, vol. 14, iss.Suppl 1, p. 139, 2013.
[Bibtex]

@article{Stetter2013,
abstract = {Poster - no abstract},
author = {Stetter, Olav and Orlandi, Javier G. and Soriano, Jordi and Battaglia, Demian and Geisel, Theo},
doi = {10.1186/1471-2202-14-S1-P139},
file = {::},
isbn = {1471220214},
issn = {1471-2202},
journal = {CNS 2013, 22nd Anual Computational Neuroscience Meeting},
keywords = {poster},
month = {jul},
number = {Suppl 1},
pages = {139},
publisher = {BioMed Central Ltd},
title = {{Network reconstruction from calcium imaging data of spontaneously bursting neuronal activity}},
url = {http://www.biomedcentral.com/1471-2202/14/S1/P139},
volume = {14},
year = {2013}
}

@inproceedings{Orlandi2013a,
abstract = {In vitro neuronal networks of dissociated hippocampal or cortical tissues are one of the most attractive model systems for the physics and neuroscience communities. Cultured neurons grow and mature, develop axons and dendrites, and quickly connect to their neighbors to establish a spontaneously active network within a week. The resulting neuronal network is characterized by a combination of excitatory and inhibitory neurons coupled through synaptic connections that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons' spiking activity and synaptic transmission, together with biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including the emergence and maintenance of periodic spontaneous activity, avalanches, propagation of fronts and synchronization. In this work we present an overview on the rich activity of cultured neuronal networks, and detail the minimal theoretical considerations needed to describe experimental observations.},
address = {Barcelona, Spain},
annote = {From Duplicate 3 (The emergence of spontaneous activity in neuronal cultures, coherence from noise - Orlandi, Javier G; Soriano, Jordi; Alvarez-Lacalle, Enrique; Teller, Sara; Casademunt, Jaume)
AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Orlandi, J.G.; Alvarez-Lacalle, E.; Teller S.; Soriano, J; Casademunt, J.},
author = {Orlandi, Javier G. and Soriano, Jordi and Alvarez-Lacalle, Enrique and Teller, Sara and Casademunt, Jaume and Soriano, Jordi and Casademunt, Jaume},
booktitle = {CNS 2013, 22nd Anual Computational Neuroscience Meeting},
doi = {10.1186/1471-2202-14-S1-P54},
file = {::},
isbn = {9780735411289},
issn = {15517616},
keywords = {neuronal cultures,poster,spontaneous activity,talk},
month = {feb},
number = {Suppl 1},
pages = {25--27},
pmid = {1000303108},
publisher = {BioMed Central Ltd},
title = {{The emergence of spontaneous activity in neuronal cultures, coherence from noise}},
url = {http://www.crm.cat/en/Activities/Pages/ActivityFoldersAndPages/Curs 2012-2013/BARCSYN2013/BARCSYN2013.aspx http://www.biomedcentral.com/1471-2202/14/S1/P54},
volume = {1510},
year = {2013}
}

Experiments on clustered neuronal cultures
Teller, S., Orlandi, J.G., Alvarez-Lacalle, E., Casademunt, J., and Soriano, J.
8th fens forum of european neuroscience societies, Barcelona, Spain, 2012.
[Bibtex]

@inproceedings{Teller2012,
address = {Barcelona, Spain},
author = {Teller, Sara and Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Casademunt, Jaume and Soriano, Jordi},
booktitle = {8th FENS forum of European Neuroscience Societies},
keywords = {poster},
month = {jul},
title = {{Experiments on clustered neuronal cultures}},
url = {http://fens2012.neurosciences.asso.fr/index.php},
year = {2012}
}

The emergence of coherent activity in neuronal cultures
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Soriano, J., and Casademunt, J.
8th fens forum of european neuroscience societies, Barcelona, Spain, 2012.
[Bibtex]

@inproceedings{Orlandi2012b,
address = {Barcelona, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
booktitle = {8th FENS forum of European Neuroscience Societies},
keywords = {poster},
month = {jul},
title = {{The emergence of coherent activity in neuronal cultures}},
url = {http://fens2012.neurosciences.asso.fr/index.php},
year = {2012}
}

Self-similarity and chaos in coupled ratchets. Unfolding the complexity of cooperative Brownian motors
Blanch-Mercader, C., Orlandi, J.G., and Casademunt, J.
Fises’11 xvii congreso de física estadística, Barcelona, Spain, 2011.
[Bibtex]

@inproceedings{Blanch-Mercader2011,
address = {Barcelona, Spain},
author = {Blanch-Mercader, Carles and Orlandi, Javier G. and Casademunt, Jaume},
booktitle = {FisEs'11 XVII Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {poster},
month = {jun},
title = {{Self-similarity and chaos in coupled ratchets. Unfolding the complexity of cooperative Brownian motors}},
url = {http://www.gefenol.es/FisEs/11/content/paneles},
year = {2011}
}

Spontaneous Activity in Neuronal Cultures: Experiments and Model
Soriano, J., Teller, S., Orlandi, J.G., Álvarez, E., Casademunt, J., and Moses, E.
Xi congreso de la sociedad de biofísica de españa, Murcia, Spain, 2011.
[Bibtex]

@inproceedings{Soriano2011,
address = {Murcia, Spain},
annote = {AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Jordi Soriano; Sara Teller; Javier Orlandi; Enric {{\'{A}}}lvarez; Jaume Casademunt; Elisha Moses},
author = {Soriano, Jordi and Teller, Sara and Orlandi, Javier G. and {\'{A}}lvarez, Enric and Casademunt, Jaume and Moses, Elisha},
booktitle = {XI Congreso de la Sociedad de Biof{\'{i}}sica de Espa{\~{n}}a},
keywords = {poster},
month = {jun},
title = {{Spontaneous Activity in Neuronal Cultures: Experiments and Model}},
url = {http://www.sbe.es/SBE-Meetings.asp},
year = {2011}
}

Experiments on Patterned Neuronal Cultures
Teller, S., Orlandi, J.G., Alvarez-Lacalle, E., Casademunt, J., Moses, E., and Soriano, J.
Fises’11 xvii congreso de física estadística, Barcelona, Spain, 2011.
[Bibtex]

@inproceedings{Teller2011a,
address = {Barcelona, Spain},
author = {Teller, Sara and Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Casademunt, Jaume and Moses, Elisha and Soriano, Jordi},
booktitle = {FisEs'11 XVII Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {poster},
month = {jun},
title = {{Experiments on Patterned Neuronal Cultures}},
url = {http://www.gefenol.es/FisEs/11/content/paneles},
year = {2011}
}

Local noise amplification and synaptic depression control the spontaneous activity in neuronal cultures
Orlandi, J.G., Alvarez-Lacalle, E., Teller, S., Soriano, J., and Casademunt, J.
Ninth göttingen meeting of the german neuroscience society, göttingen, germany. march 23-27, 2011, G{ö}ttingen, Germany, 2011.
[Bibtex]

@inproceedings{Orlandi2011a,
address = {G{{\"{o}}}ttingen, Germany},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
booktitle = {Ninth G{\"{o}}ttingen Meeting of the German Neuroscience Society, G{\"{o}}ttingen, Germany. March 23-27, 2011},
keywords = {poster},
month = {mar},
title = {{Local noise amplification and synaptic depression control the spontaneous activity in neuronal cultures}},
url = {https://www.nwg-goettingen.de/2011/},
year = {2011}
}

@inproceedings{Orlandi2011b,
address = {Barcelona, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Teller, Sara and Soriano, Jordi and Casademunt, Jaume},
booktitle = {BARCSYN: 2011 Barcelona Computational and Systems Neuroscience Meeting},
keywords = {poster,talk},
month = {feb},
title = {{Unraveling Spontaneous Activity in Neuronal Cultures}},
url = {http://www.crm.cat/en/Activities/Pages/ActivityFoldersAndPages/Curs 2011-2012/BARCSYN2011/default.aspx},
year = {2011}
}

Monitoring Dynamics in Living Neuronal Networks
Teller, S., Orlandi, J.G., Alvarez-Lacalle, E., Casademunt, J., and Soriano, J.
Barcsyn: 2011 barcelona computational and systems neuroscience meeting, 2011.
[Bibtex]

@inproceedings{Teller2011,
annote = {AUTHOR MODIFIED BY PROCESS. ORIGINAL IS: Sara Teller; Javier Orlandi; Enric {{\'{A}}}lvarez-Lacalle; Jaume Casademunt; Jordi Soriano},
author = {Teller, Sara and Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Casademunt, Jaume and Soriano, Jordi},
booktitle = {BARCSYN: 2011 Barcelona Computational and Systems Neuroscience Meeting},
keywords = {poster},
title = {{Monitoring Dynamics in Living Neuronal Networks}},
url = {http://www.crm.cat/en/Activities/Pages/ActivityFoldersAndPages/Curs 2011-2012/BARCSYN2011/default.aspx},
year = {2011}
}

Modelling Spontaneous Activity in Neuronal Cultures
Orlandi, J.G., Alvarez-Lacalle, E., Amigó, N., Soriano, J., and Casademunt, J.
Iv spanish portuguese biophysical congress, Zaragoza, Spain, 2010.
[Bibtex]

@inproceedings{Orlandi2010c,
address = {Zaragoza, Spain},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Amig{\'{o}}, N and Soriano, Jordi and Casademunt, Jaume},
booktitle = {IV Spanish Portuguese Biophysical Congress},
keywords = {poster},
month = {jul},
title = {{Modelling Spontaneous Activity in Neuronal Cultures}},
url = {http://www.sbe.es/SBE-Meetings.asp},
year = {2010}
}

Nucleation and front propagation in patterned neuronal networks.
Orlandi, J.G., Alvarez-Lacalle, E., Amigó, N., Soriano, J., and Casademunt, J.
7th fens forum of european neuroscience, Amsterdam, The Netherlands, 2010.
[Bibtex]

@inproceedings{Orlandi2010,
address = {Amsterdam, The Netherlands},
author = {Orlandi, Javier G. and Alvarez-Lacalle, Enrique and Amig{\'{o}}, N and Soriano, Jordi and Casademunt, Jaume},
booktitle = {7th FENS forum of European Neuroscience},
keywords = {poster},
month = {jul},
title = {{Nucleation and front propagation in patterned neuronal networks.}},
url = {http://fens2010.neurosciences.asso.fr/},
year = {2010}
}

Cooperativity of single-headed kinesin motors in axonal transport
Orlandi, J.G. and Casademunt, J.
Iv spanish portuguese biophysical congress, London, UK, 2010.
[Bibtex]

@inproceedings{Orlandi2010a,
address = {London, UK},
author = {Orlandi, Javier G. and Casademunt, Jaume},
booktitle = {IV Spanish Portuguese Biophysical Congress},
keywords = {poster},
month = {jun},
title = {{Cooperativity of single-headed kinesin motors in axonal transport}},
url = {http://www.sbe.es/SBE-Meetings.asp},
year = {2010}
}

Quasi-deterministic collective ratchets. Some exact results.
Blanch-Mercader, C., Orlandi, J.G., and Casademunt, J.
Fises ’09 xvi congreso de física estadística, Huelva, Spain, 2009.
[Bibtex]

@inproceedings{Blanch-Mercader2009,
address = {Huelva, Spain},
author = {Blanch-Mercader, Carles and Orlandi, Javier G. and Casademunt, Jaume},
booktitle = {FiSeS '09 XVI Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {poster},
month = {sep},
title = {{Quasi-deterministic collective ratchets. Some exact results.}},
year = {2009}
}

Collective dynamics of interacting Brownian motors under unequal loading
Orlandi, J.G., Blanch-Mercader, C., Brugués, J., and Casademunt, J.
Fises ’09 xvi congreso de física estadística, Huelva, Spain, 2009.
[Bibtex]

@inproceedings{Orlandi2009b,
address = {Huelva, Spain},
author = {Orlandi, Javier G. and Blanch-Mercader, Carles and Brugu{\'{e}}s, J and Casademunt, Jaume},
booktitle = {FiSeS '09 XVI Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {poster},
month = {sep},
title = {{Collective dynamics of interacting Brownian motors under unequal loading}},
year = {2009}
}

Cooperativity of single-headed kinesin motors
Orlandi, J.G., Blanch-Mercader, C., and Casademunt, J.
Fises ’09 xvi congreso de física estadística, Huelva, Spain, 2009.
[Bibtex]

@inproceedings{Orlandi2009,
address = {Huelva, Spain},
author = {Orlandi, Javier G. and Blanch-Mercader, Carles and Casademunt, Jaume},
booktitle = {FiSeS '09 XVI Congreso de F{\'{i}}sica Estad{\'{i}}stica},
keywords = {poster},
month = {sep},
title = {{Cooperativity of single-headed kinesin motors}},
year = {2009}
}

Popular science

Dinámica colectiva de las redes neuronales
Casademunt, J., Orlandi, J.G., and Soriano, J.
Mente y cerebro – investigación y ciencia (spanish scientific american), vol. 67, p. 49–50, 2014.
[Bibtex]

@article{Casademunt2014,
author = {Casademunt, Jaume and Orlandi, Javier G. and Soriano, Jordi},
journal = {Mente y Cerebro - Investigaci{\'{o}}n y Ciencia (Spanish Scientific American)},
keywords = {popular},
month = {jul},
pages = {49--50},
title = {{Din{\'{a}}mica colectiva de las redes neuronales}},
url = {http://www.investigacionyciencia.es/mente-y-cerebro/numeros/2014/7/dinmica-colectiva-de-las-redes-neuronales-12228},
volume = {67},
year = {2014}
}

Avalanchas mentales
Orlandi, J.G.
Revista española de física (journal of the spanish royal society of physics), vol. 28, iss.1, p. 43–44, 2014.
[Bibtex]

@article{Orlandi2014,
author = {Orlandi, Javier G.},
journal = {Revista Espa{\~{n}}ola de F{\'{i}}sica (Journal of the Spanish Royal Society of Physics)},
keywords = {popular},
month = {mar},
number = {1},
pages = {43--44},
title = {{Avalanchas mentales}},
url = {http://www.revistadefisica.es/index.php/ref/issue/view/130/showToc},
volume = {28},
year = {2014}
}

Research coverage (editorals, news and views)

Focus amidst the noise
Beggs, J.M.
Nature physics, vol. 9, iss.9, p. 533–534, 2013.
[Bibtex]

@article{Beggs2013,
abstract = {High-resolution imaging of neuronal networks reveals that spontaneous bursts of collective activity are a consequence of an implosive concentration of noise.},
author = {Beggs, John M.},
doi = {10.1038/nphys2707},
file = {::},
issn = {1745-2473},
journal = {Nature Physics},
keywords = {highlights},
month = {sep},
number = {9},
pages = {533--534},
publisher = {Nature Publishing Group},
title = {{Focus amidst the noise}},
url = {http://www.nature.com/articles/nphys2707},
volume = {9},
year = {2013}
}