{"id":70,"date":"2009-07-04T00:00:41","date_gmt":"2009-07-03T22:00:41","guid":{"rendered":"http:\/\/javierorlandi.com\/?p=70"},"modified":"2015-03-24T22:04:22","modified_gmt":"2015-03-24T20:04:22","slug":"theoretical-study-of-a-membrane-channel-gated-by-atp","status":"publish","type":"post","link":"http:\/\/javierorlandi.com\/?p=70","title":{"rendered":"Theoretical study of a membrane channel gated by ATP"},"content":{"rendered":"<p style=\"text-align: justify;\">J. G. Orlandi and J. M. Sancho<\/p>\n<p style=\"text-align: justify;\">EPJ-E, 29-3, pp. 329-336 (<strong>2009<\/strong>)<!--more--><\/p>\n<p style=\"text-align: justify;\" align=\"justify\"><b>Abstract:<\/b><br \/>\nWe study channel transport across biomembranes. We propose a model that couples the diffusive dynamics with the gating process via a two-state ratchet mechanism. This gating process is governed by ATP binding and hydrolysis, and the process exhibits Michaelis-Menten enzymatic kinetics. The particle flow and permeability of the channel are studied both analytically and numerically in the steady-state regime, while working between fixed concentrations. The results are compared with simpler models and with experimental data. Also, a simulation framework, that allows high flexibility in parameter exploration, is introduced.<\/p>\n<p style=\"text-align: center;\" align=\"justify\">[\u00a0<a href=\"http:\/\/dx.doi.org\/10.1140\/epje\/i2009-10483-9\" target=\"\t\">DOI<\/a>\u00a0| <a href=\"http:\/\/javierorlandi.com\/wp-content\/uploads\/2009\/07\/orlandi2009.pdf\">PDF<\/a>]<\/p>\n<p style=\"text-align: center;\" align=\"justify\"><a href=\"http:\/\/javierorlandi.com\/wp-content\/uploads\/2009\/07\/2009_Orlandi.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-137\" style=\"border: 1px solid black;\" src=\"http:\/\/javierorlandi.com\/wp-content\/uploads\/2009\/07\/2009_Orlandi.png\" alt=\"2009_Orlandi\" width=\"621\" height=\"877\" srcset=\"http:\/\/javierorlandi.com\/wp-content\/uploads\/2009\/07\/2009_Orlandi.png 621w, http:\/\/javierorlandi.com\/wp-content\/uploads\/2009\/07\/2009_Orlandi-212x300.png 212w\" sizes=\"(max-width: 621px) 100vw, 621px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>J. G. Orlandi and J. M. Sancho EPJ-E, 29-3, pp. 329-336 (2009)<\/p>\n","protected":false},"author":1,"featured_media":71,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,12],"tags":[],"_links":{"self":[{"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/posts\/70"}],"collection":[{"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=70"}],"version-history":[{"count":11,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/posts\/70\/revisions"}],"predecessor-version":[{"id":336,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/posts\/70\/revisions\/336"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=\/wp\/v2\/media\/71"}],"wp:attachment":[{"href":"http:\/\/javierorlandi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=70"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=70"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/javierorlandi.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}